< Bioinfo | Making sense of data


09/90-12/95 Ph.D., Genetics Programme, University of British Columbia, Vancouver, B.C., under the supervision of Dr. Connie J. Eaves at the Terry Fox Laboratory for Hematology/Oncology. My first introduction to stem cells in all their glory and complexity by a pioneer in the field.
09/82-04/87 Honours B.Math., Co-op Computer Science, University of Waterloo, Waterloo, Ont. Co-op Work Terms: IBM (2 terms), National Research Council of Canada, Canadian International Development Agency, Bell Northern Research (now Nortel). In-depth and hands on training in rigourous thought, mathematics, statistics and computer science at a world-class Faculty of Mathematics.

Positions and Employment

04/12-present & 06/00-12/03 Independent Bioinformatics Consultant, Bioinfo, Plantagenet, Ontario. Expert data analysis, integration and visualization of high-throughput and multi-dimensional data.
06/05-03/12 Computational Biologist, Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA. In collaboration with many talented and driven researchers, chief among them Drs. Andrew Kung (now at Columbia University Medical Center), Jay Bradner and Vivienne Rebel of the University of Texas Health Sciences Center at San Antonio, I developed novel bioinformatics pipelines to analyze data from high-throughput platforms and integrate these data with other large-scale information sources, such as Gene Ontology and protein-protein interaction networks. Such integrative approaches allowed us to test existing hypotheses and to generate further testable predictions. In each of the projects, my deep understanding of the underlying biology allowed me to more effectively leverage data and, in some cases, help drive the research.
01/04-12/04 Non-gainfully but enjoyably busy living in Beijing, PRC. Met some great people, sampled lots of delicious food, travelled as much as I could, learned a little Mandarin, something about Chinese culture and quite a lot of Perl and SQL.
07/00-12/03 & 01/99-06/00 Research Associate & Post-Doctoral Fellow, Ottawa Regional Cancer Centre, Ottawa, Ont., under the direction of Dr. Michael W. McBurney. My first exposure to the epigenetic regulation of gene expression. I researched gene silencing as a potential factor in tumour development, focusing specifically on the consequences of ablating the mammalian histone deacetylase Silent Information Regulator 2 (SIR2) protein. Also my first foray into microarray analysis to complement histological and molecular characterization of knock-out animals.
06/96-01/99 Post-Doctoral Fellow, Loeb Research Institute, Ottawa, Ont., under the direction of Dr. Robert J. Haché. A comprehensive introduction to molecular biology and endocrinology to round out my Ph.D.'s extensive experience of cell culture and flow cytometry. I examined the transcriptional effects of glucocorticoid receptor-homeodomain (Hox) protein interactions.
12/87-08/90 Applications Support and Software Development Consultant, A.P.G. Inc., Ottawa, Ont.

Last update: 13 September 2013